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Study investigated therapy of sufferers with AML and preliminary findings counsel that EP0042 had acceptable security and tolerability, with proof of illness stabilisation

Ellipses Pharma Limited (“Ellipses”), a worldwide drug improvement firm targeted on accelerating the event of recent oncology therapies, has offered preliminary information from the primary in human section 1/2 trial of EP0042, a twin FLT-3 an Aurora kinase inhibitor, in sufferers with acute myeloid leukaemia (AML) on the sixty fourth American Society of Hematology (ASH) Annual Meeting in New Orleans, Louisiana.

EP0042 is being developed as a brand new potential therapy to fight acquired resistance to FLT3 inhibitors in sufferers with AML. Around one third of sufferers with AML are identified with FLT3-mutations, that are related to a better threat of relapse and poor medical end result.1 The preliminary information, from the continued dose ranging module of the trial, demonstrated that EP0042 had acceptable security and tolerability with proof of extended illness stabilisation in quite a lot of closely pre-treated sufferers.2 No dose-limiting toxicities have been noticed, and the rising antagonistic occasion profile of EP0042 seems to be characterised by febrile neutropenia, fatigue diarrhoea, peripheral oedema, dizziness, and ataxia . The information have been offered by Dr David Taussig, Consultant Haematologist at The Royal Marsden NHS Foundation Trust and Honorary Team Leader in Acute Leukaemia on the Institute for Cancer Research, in the course of the poster session on Sunday, December 11, 2022.

The preliminary information relies upon 25 sufferers throughout 6 dose cohorts together with sufferers with FLT3 mutated and wild kind AML on the level of enrolment. The median variety of prior therapies was 2 (vary 1-6), with quite a lot of sufferers having obtained a previous FLT3 inhibitor.

Once a really useful Phase-2 dose is confirmed, Ellipses intends to proceed evaluating EP0042 as a monotherapy and discover EP0042 together with established normal therapies.

Dr David Taussig, Consultant Haematologist at The Royal Marsden NHS Foundation Trust and Chief Investigator, stated:

“I’m excited to guide the primary in-human medical trial of EP0042, a drug which I hope will in the end enhance outcomes of sufferers with AML, for whom present therapy regimens are sometimes ineffective. I stay up for constructing on this early medical information alongside my colleagues, as we take this probably essential candidate additional into the clinic.”

Dr Rajan Jethwa, CEO of Ellipses, stated:

“Ellipses’ distinctive method to drug improvement permits us to speed up medication via the clinic and shorten the period of time it takes for important therapies to achieve most cancers sufferers. The preliminary information from EP0042 is a primary step in probably uncovering the promise that this compound holds and in the end serving to AML sufferers with restricted therapy choices.”

About EP0042

EP0042 is a twin FLT3 and Aurora kinase inhibitor underneath improvement as a possible therapy for AML sufferers who’ve developed FLT3 inhibitor resistance. Dual inhibition of FLT3 and Aurora kinase has been proven to beat acquired resistance to selective FLT3 inhibition each in vitro and in vivo.3

About acute myeloid leukaemia

Acute myeloid leukaemia (AML) is a most cancers of the bone marrow, which begins to supply extra volumes of monocytes and granulocytes. It is likely one of the most typical kinds of leukaemia in adults. Approximately 20,000 persons are identified with AML within the US every year,4 and an additional 3,100 within the UK, with round 40% of circumstances being identified in folks over the age of 75.5 The 5-year survival fee following an preliminary analysis is presently 15%.6

About Ellipses Pharma Limited

Ellipses Pharma is a worldwide drug improvement firm primarily based in London, targeted on accelerating the event of most cancers medicines and coverings via an progressive drug improvement mannequin that mixes unbiased vetting to de-risk preliminary asset choice with an uninterrupted funding movement to attenuate the time it takes to advance lead merchandise via medical trials and attain sufferers.

For extra data, please go to ellipses.life.


Ellipses Pharma Ltd

Suzanne Wood

[email protected]


Source: Ellipses Pharma Limited


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By Seth A. Dunbar

Seth Dunbar leads clinical research study operations and quality & compliance. He is experienced working with teams to help drug sponsors better leverage eSource data. With 10+ years of experience Seth brings expertise developing eClinical services that integrate data and technology to help companies optimise study execution.

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