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Exscientia and Sanofi set up strategic analysis collaboration to develop AI-driven pipeline of precision-engineered medicines

Collaborative efforts intention to speed up drug discovery and enhance medical success

Agreement to make the most of Exscientia’s AI-based capabilities and personalised drugs platform from goal identification by means of affected person choice

Research can be centered on as much as 15 novel small molecule candidates throughout oncology and immunology

Exscientia will obtain an upfront money cost of $100 million with the potential of $5.2 billion in complete milestones plus tiered royalties

PARIS, OXFORD, and BOSTON – January 7, 2022 – Sanofi and Exscientia introduced in the present day a groundbreaking analysis collaboration and license settlement to develop as much as 15 novel small molecule candidates throughout oncology and immunology, leveraging Exscientia’s end-to-end AI-driven platform using precise affected person samples. The corporations have been working collectively since 2016 and in 2019, Sanofi in-licensed Exscientia’s novel bispecific small molecule candidate able to focusing on two distinct targets in irritation and immunology.

“We stay up for deepening our work with Exscientia, a pacesetter in leveraging AI to modernize all points of drug discovery and growth,” stated Frank Nestle, Global Head of Research and Chief Scientific Officer, Sanofi. “Sanofi’s collaboration with Exscientia goals to remodel how we uncover and develop new small molecule medicines for most cancers and immune-mediated illnesses. Application of refined AI and machine studying strategies is not going to solely shorten drug discovery timelines, however may also assist to design increased high quality and higher focused medicines for sufferers.”

Exscientia and Sanofi will collaborate to determine and choose goal tasks, leveraging Exscientia’s personalised drugs platform. The platform permits a “patient-first” method by means of integrating major human tissue samples into early goal and drug discovery analysis. By doing so, Exscientia scientists can combine affected person, illness, and clinically related information into selections on potential new drugs candidates earlier within the drug creation course of. In addition to focus on discovery, Exscientia will lead small molecule drug design and lead optimization actions as much as growth candidate nomination, with Sanofi assuming duty for preclinical and medical growth, manufacturing and commercialization.

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“It is immensely thrilling to collaborate with Sanofi with our purpose of realizing the total potential of AI to ship the following technology of most cancers and immunology medicines,” stated Andrew Hopkins, DPhil, CEO and founding father of Exscientia. “Our AI-driven platform might be leveraged throughout drug discovery, translational analysis and growth, with purposes starting from bettering the precision drugs and high quality of drug candidates to enriching for affected person choice in medical trials. Our expanded collaboration with Sanofi will utilise the breadth of our platform to check AI-designed drug candidates towards affected person tissue fashions, doubtlessly offering much better accuracy than typical approaches equivalent to mouse fashions. When you contemplate the change this represents – testing candidates towards precise human tissue years earlier than a medical trial – it’s transformative.”

Under the phrases of the settlement, Exscientia will obtain an upfront money cost of $100 million from Sanofi and can be eligible to obtain future analysis, translational, medical growth, regulatory and industrial milestone funds of as much as roughly $5.2 billion in mixture, if all milestones for all applications are achieved. In the case that Sanofi commercializes a therapeutic from the collaboration, Exscientia may also be eligible to obtain tiered royalties on product gross sales starting from high-single-digits to mid-teens and an choice for medical co-investment to extend the royalty charge as much as 21% on web gross sales of co-funded merchandise. The upfront money cost of $100 million is anticipated to be mirrored within the first quarter 2022 monetary outcomes of Exscientia as money inflows from collaborations and acknowledged as income over the length of the settlement.

About Exscientia

Exscientia is an AI-driven pharmatech firm dedicated to discovering, designing and creating the absolute best medication within the quickest and simplest method. Exscientia developed the first-ever practical precision oncology platform to efficiently information remedy choice and enhance affected person outcomes in a potential interventional medical research, in addition to to progress AI-designed small molecules into the medical setting. Our pipeline demonstrates our skill to quickly translate scientific ideas into precision-designed therapeutic candidates, with greater than 25 tasks advancing, together with the primary three AI-designed drug candidates to enter Phase 1 medical trials.

Exscientia has places of work in Oxford, Vienna, Dundee, Boston, Miami, and Osaka. For extra data go to us on https://www.exscientia.ai or comply with us on Twitter @exscientiaAI.

About Sanofi

Sanofi is devoted to supporting folks by means of their well being challenges. We are a worldwide biopharmaceutical firm centered on human well being. We stop sickness with vaccines, present progressive therapies to battle ache and ease struggling. We stand by the few that suffer from uncommon illnesses and the hundreds of thousands with long-term persistent circumstances.

With greater than 100,000 folks in 100 nations, Sanofi is reworking scientific innovation into healthcare options across the globe.

Sanofi Media Relations Contacts
Sally Bain
Tel: +1 (781) 264-1091
Sally.Bain@sanofi.com

Sandrine Guendoul
Tel.: +33 (0)6 25 09 14 25
Sandrine.Guendoul@sanofi.com

Sanofi Investor Relations Contacts Paris
Eva Schaefer-Jansen
Arnaud Delepine
Nathalie Pham

Sanofi Investor Relations Contacts North America
Felix Lauscher

Tel.: +33 (0)1 53 77 45 45
investor.relations@sanofi.com
https://www.sanofi.com/en/investors/contact

Exscientia Media Relations Contact
Amanda Galgay
agalgay@exscientia.ai

Exscientia Investor Relations Contact
Sara Sherman
traders@exscientia.ai

Exscientia Forward-Looking Statements

This press launch accommodates sure forward-looking statements throughout the which means of the “secure harbor” provisions of the Private Securities Litigation Reform Act of 1995, together with statements with regard to Exscientia’s expectations relating to the power of its AI-supported personalised drugs platform to design and develop novel small molecule candidates throughout oncology and immunology. Words equivalent to “anticipates,” “believes,” “expects,” “intends,” “tasks,” “anticipates,” and “future” or related expressions are meant to determine forward-looking statements. These forward-looking statements are topic to the uncertainties inherent in predicting future outcomes and circumstances and no assurance might be provided that the AI-supported personalised drugs platform mentioned above can be profitable in creating novel small molecule candidates within the oncology and immunology fields or attaining any milestone in its settlement with Sanofi. Exscientia undertakes no obligation to publicly replace or revise any forward-looking statements, whether or not on account of new data, future occasions or in any other case, besides as could also be required by legislation.

Sanofi Forward-Looking Statements

This press launch accommodates forward-looking statements as outlined within the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that aren’t historic info. These statements embody projections and estimates and their underlying assumptions, statements relating to plans, aims, intentions and expectations with respect to future monetary outcomes, occasions, operations, providers, product growth and potential, and statements relating to future efficiency. Forward-looking statements are usually recognized by the phrases “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans” and related expressions. Although Sanofi’s administration believes that the expectations mirrored in such forward-looking statements are affordable, traders are cautioned that forward-looking data and statements are topic to numerous dangers and uncertainties, a lot of that are tough to foretell and usually past the management of Sanofi, that would trigger precise outcomes and developments to vary materially from these expressed in, or implied or projected by, the forward-looking data and statements. These dangers and uncertainties embody amongst different issues, the uncertainties inherent in analysis and growth, future medical information and evaluation, together with submit advertising and marketing, selections by regulatory authorities, such because the FDA or the EMA, relating to whether or not and when to approve any drug, gadget or organic utility that could be filed for any such product candidates in addition to their selections relating to labelling and different issues that would have an effect on the provision or industrial potential of such product candidates, the truth that product candidates if authorized will not be commercially profitable, the longer term approval and industrial success of therapeutic alternate options, Sanofi’s skill to profit from exterior development alternatives, to finish associated transactions and/or get hold of regulatory clearances, dangers related to mental property and any associated pending or future litigation and the final word consequence of such litigation, traits in change charges and prevailing rates of interest, risky financial and market circumstances, value containment initiatives and subsequent modifications thereto, and the impression that COVID-19 may have on us, our prospects, suppliers, distributors, and different enterprise companions, and the monetary situation of any one in all them, in addition to on our staff and on the worldwide economic system as a complete. Any materials impact of COVID-19 on any of the foregoing may additionally adversely impression us. This state of affairs is altering quickly and extra impacts could come up of which we aren’t at the moment conscious and should exacerbate different beforehand recognized dangers. The dangers and uncertainties additionally embody the uncertainties mentioned or recognized within the public filings with the SEC and the AMF made by Sanofi, together with these listed below “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in Sanofi’s annual report on Form 20-F for the 12 months ended December 31, 2020. Other than as required by relevant legislation, Sanofi doesn’t undertake any obligation to replace or revise any forward-looking data or statements.

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By Seth A. Dunbar

Seth Dunbar leads clinical research study operations and quality & compliance. He is experienced working with teams to help drug sponsors better leverage eSource data. With 10+ years of experience Seth brings expertise developing eClinical services that integrate data and technology to help companies optimise study execution.

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