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A NEW trial of a “game-changing” tablet to fight Covid-19 has opened in Southampton.

The antiviral drug, Molnupiravir, was just lately accepted to be used within the UK for folks with gentle to average coronavirus signs who’re at further threat on account of underlying situations.

But now, a trial to check the remedy within the wider neighborhood has opened on the on the NIHR (CRF) at University Hospital Southampton.

Molnupiravir works by interfering with the virus’ replication and stopping it from multiplying which retains virus ranges low within the physique, decreasing its severity.

Coming as a part of the AGILE COVID-19 Drug Testing Initiative run by the Clinical Trials Unit, folks from throughout the South are actually being invited to participate.

Open to all adults with laboratory confirmed Covid-19, individuals who take part within the trial might be inside 5 days of their first signs and will be vaccinated or unvaccinated.

A complete of 180 folks will participate so as to consider the security and optimum dose of the drug in a wider inhabitants of sufferers.

Professor Christopher Edwards, Principal Investigator for AGILE in Southampton and Associate Director of the Southampton CRF.

Professor Christopher Edwards, Principal Investigator for AGILE in Southampton and Associate Director of the Southampton CRF, stated: “Despite the massive success of the NHS COVID-19 vaccination programme, we nonetheless want to search out therapies for individuals who do contract the virus to forestall them creating extra severe illness and cut back hospital admissions.

“Having a pill, which is straightforward to manage and is efficient in opposition to the virus is game-changing, and we’re excited to be concerned within the AGILE trial of molnupiravir.”

Samples collected from individuals might be analysed within the laboratory to additional achieve a greater understanding of which sufferers and Covid-19 variants molnupiravir works in, within the hope it’s appropriate for everybody in the neighborhood to entry.

Professor Gareth Griffiths, Director of the NIHR Southampton Clinical Trials Unit

Professor Gareth Griffiths, Director of the NIHR Southampton Clinical Trials Unit, stated: “It is incredible that molnupiravir has been accepted to be used in susceptible members of the neighborhood.

“However, the earlier trials which led to this resolution had been carried out in unvaccinated folks in the beginning of the pandemic and we have to perceive extra about who may gain advantage from molnupiravir and the way it works, for instance does it work as effectively in these with Omicron.”

The trial has presently recruited 139 individuals from throughout the UK.

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By Seth A. Dunbar

Seth Dunbar leads clinical research study operations and quality & compliance. He is experienced working with teams to help drug sponsors better leverage eSource data. With 10+ years of experience Seth brings expertise developing eClinical services that integrate data and technology to help companies optimise study execution.

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