The Nationwide Institute of Allergy and Infectious Illnesses (NIAID), a part of the Nationwide Institutes of Well being, at present introduced the scientific investigators and establishments that may lead 4 NIH HIV scientific trials networks over the subsequent seven years to conduct the progressive, environment friendly scientific analysis wanted to speed up progress in opposition to the HIV pandemic. NIAID additionally awarded grants to 35 U.S. and worldwide establishments chosen as HIV scientific trials items (CTUs). NIAID and co-funding NIH Institutes intend to supply roughly $375.3 million within the first 12 months to help the networks.
“Attaining a sturdy finish to the HIV pandemic would require continued improvement of recent HIV prevention and remedy methods, in addition to optimum implementation of present instruments,” stated NIAID Director Anthony S. Fauci, M.D. “The brand new community construction will improve the effectivity and effectiveness of NIH’s HIV scientific trial operations to expediently handle the important analysis questions that may carry us nearer to this aim, whereas all the time guaranteeing the protection of scientific trial individuals.”
The method of refining the NIH HIV scientific trials networks started in 2017 and concerned intensive consultations with researchers, clinicians, advocates, folks with or prone to HIV, and different stakeholders. The brand new, streamlined community construction will cut back administrative and oversight prices, permitting extra funds to be allotted to scientific trials to advance 4 key areas of analysis emphasis: HIV prevention; HIV vaccines; HIV/AIDS grownup therapeutics; and HIV/AIDS maternal, adolescent and pediatric therapeutics. The networks even have the pliability to leverage their infrastructure to quickly reply to rising infectious ailments, reminiscent of coronavirus illness 2019 (COVID-19).
The brand new construction contains one community that may concentrate on improvement of a secure, efficient and sturdy preventive HIV vaccine, and one that may work to advance an array of non-vaccine HIV prevention merchandise and methods to satisfy the wants and preferences of various populations worldwide. Two therapeutics networks will develop and consider potential new remedies and remedy methods for HIV and HIV-related issues and co-infections. One in every of these networks will concentrate on adults, whereas the opposite will concentrate on infants, youngsters, adolescents, and pregnant and postpartum ladies. HIV prevention and vaccine analysis for the maternal, pediatric and adolescent populations can be led by the HIV prevention and vaccine networks, with help from the therapeutics community centered on these populations.
The 4 networks will direct, coordinate and conduct NIH-funded scientific analysis worldwide in shut collaboration with each other, NIAID, different companion NIH Institutes and Facilities, trade and non-governmental analysis organizations. Every community is led by a management and operations heart (LOC) and features a laboratory heart (LC) and a statistical and knowledge administration heart (SDMC). The principal investigators, establishments and grant numbers for these awards are as follows:
HIV Vaccine Trials Community (HVTN)
- LOC: Lawrence Corey, Dan H. Barouch, Glenda E. Grey, Georgia D. Tomaras; Fred Hutchinson Most cancers Analysis Heart, Seattle; 2 UM1 AI068614-15
- LC: Margaret J. McElrath; Fred Hutchinson Most cancers Analysis Heart, Seattle; 2 UM1 AI068618-15
- SDMC: Peter B. Gilbert, Yunda Huang, Holly Janes; Fred Hutchinson Most cancers Analysis Heart, Seattle; 2 UM1 AI068635-15
HIV Prevention Trials Community (HPTN)
- LOC: Myron S. Cohen, Wafaa M. El-Sadr; Household Well being Worldwide, Durham, North Carolina; 2 UM1 AI068619-15
- LC: Susan H. Eshleman; Johns Hopkins College, Baltimore; 2 UM1 AI068613-15
- SDMC: Deborah J. Donnell; Fred Hutchinson Most cancers Analysis Heart, Seattle; 2 UM1 AI068617-15
AIDS Medical Trials Group (ACTG)
- LOC: Judith S. Currier, Joseph J. Eron; College of California Los Angeles; 2 UM1 AI068636-15
- LC: Grace M. Aldrovandi; College of California Los Angeles; 2 UM1 AI106701-08
- SDMC: Michael D. Hughes, Marlene Cooper; Harvard Faculty of Public Well being, Boston; 2 UM1 AI068634-15
Worldwide Maternal Pediatric Adolescent AIDS Medical Trials Community (IMPAACT)
- LOC: Sharon A. Nachman; Johns Hopkins College, Baltimore; 2 UM1 AI068632-15
- LC: Grace M. Aldrovandi; College of California Los Angeles; 2 UM1 AI106716-09
- SDMC: David E. Shapiro, Marlene Cooper; Harvard Faculty of Public Well being, Boston; 2 UM1 AI068616-15
The 35 CTUs will present scientific and administrative experience, in addition to the infrastructure to conduct scientific trials throughout the networks. An entire record of CTUs, together with principal investigators and their affiliations, is available online. Every CTU helps as much as eight scientific analysis websites. Collectively, the CTUs help 101 scientific analysis websites in 18 international locations throughout North America, South America, Africa and Asia. This contains 45 websites in the USA. View a map displaying the scientific analysis web site places.
The opposite NIH Institutes that may collaborate with a number of of the HIV scientific trials networks embrace the Eunice Kennedy Shriver Nationwide Institute of Little one Well being and Human Growth (NICHD); the Nationwide Institute of Dental and Craniofacial Analysis (NIDCR); the Nationwide Institute on Drug Abuse (NIDA); the Nationwide Institute of Psychological Well being (NIMH); and the Nationwide Institute of Neurological Issues and Stroke (NINDS).
To study extra about these new awards and the method to refine NIH’s HIV scientific trials networks, see NIAID’s Refining the HIV Clinical Trials Enterprise web site.
NIAID conducts and helps research–at NIH, all through the USA, and worldwide–to examine the causes of infectious and immune-mediated ailments, and to develop higher technique of stopping, diagnosing and treating these diseases. Information releases, truth sheets and different NIAID-related supplies can be found on the NIAID website.
In regards to the Nationwide Institutes of Well being (NIH):
NIH, the nation’s medical analysis company, contains 27 Institutes and Facilities and is a element of the U.S. Division of Well being and Human Companies. NIH is the first federal company conducting and supporting primary, scientific, and translational medical analysis, and is investigating the causes, remedies, and cures for each widespread and uncommon ailments. For extra details about NIH and its packages, go to http://www.
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