By Thomas Laage, M.D., MPH, Director, Product Improvement Consulting and Regulatory Medical Writing Help
Adaptive design is a kind of scientific trial methodology that comes with prospectively deliberate alternatives for modification of a number of elements of a examine’s design or its hypotheses primarily based on interim evaluation of examine knowledge. Explicitly planning these pre-specified adjustments helps to keep up scientific integrity whereas additionally introducing higher flexibility within the scientific analysis setting. The main goals of adaptive design are to make trials extra environment friendly, informative, and prone to display important scientific results in investigational merchandise. And such improvements are essential in at the moment’s scientific analysis local weather the place excessive attrition charges, prolonged analysis and improvement applications, and skyrocketing prices are frequent.
To this point, adaptive design methods have been particularly helpful for uncommon illness analysis generally and uncommon oncology specifically. Learn extra to see how the savvy software of adaptive trial design compares to standard examine designs.