Figuring out and monitoring antagonistic occasions (AEs) is crucial to defending analysis contributors and making certain the integrity of the analysis trial. This whitepaper examines key elements in antagonistic occasion identification and monitoring, with a particular give attention to IND research, incorporating an unfolding case examine after the expedited reporting data is shared. The primary part focuses on an outline of AEs, together with a fast definition assessment. The second part discusses antagonistic occasion evaluation, specializing in AE terminology, severity ranking scales, and attribution evaluation. The third part examines AE assortment documentation. The fourth and closing part discusses expedited reporting of antagonistic occasions to each the sponsor in addition to to the IRB.